Inhibition of brain over excited protein and find more than a hundred kinds of – Science and technol

Inhibition of brain hyperexcitability protein found hundreds of kinds of science and technology — original title: inhibition of brain hyperexcitability protein found hundreds of kinds of science and technology daily Washington 7 September Xinhua (reporter Liu Haiying) Duke University researchers in the latest issue of "science" magazine published a paper called the brain inhibitory synaptic excitability than simple the synaptic assertion is wrong. They used a new biometric technology to find more than a hundred proteins that have not been found in inhibitory synapses. This discovery not only provides a new clue for the treatment of brain diseases, but also shows that the complexity of the brain is far beyond imagination. Synapse is the key part of the connection between neurons and the transmission of information. According to the influence of the activity of neurons, it can be divided into two categories: excitatory and inhibitory synapses. In the past, it has been suggested that inhibitory synapses are more simple than excitatory synapses, because they have relatively few types of proteins. Previously, scientists found about 40 proteins in inhibitory synapses, these proteins not only play a key role in preventing the brain over excited, but also shape the pattern of brain signals. The Duke University researchers used BioID biometric technology, using a bacterial enzyme to identify proteins in the mouse brain inhibitory synapses, and found 140 new proteins. "Over the past 50 years, these proteins have been locked into the safe, and today we opened the safe." The researchers described the discovery as a surprise. Genome wide association studies show that 27 of these proteins are associated with autism, mental retardation and epilepsy. The study of these proteins may provide a new way to understand and treat these diseases. Although most of the proteins are known to function, the function of the two proteins is unclear, even if the genome sequencing does not provide clues. The researchers named these two proteins as inhibitory synaptic 1 (InSyn1) and inhibitory synapse (InSyn2) (). The study found that the level of InSyn1 protein in neurons decreased, which led to the over excitation of the surrounding brain tissue, which indicated that the protein plays a very important role in the normal function of inhibitory synapses. The researchers say the new findings suggest that the brain is far more complex than we thought. The discovery of such a variety of proteins in the inhibitory synapse, to the future treatment of epilepsy and other brain diseases, as well as long-term memory formation process, provides a good clue. (commissioning editor Wei Yan and Zhao Zhuqing)相关的主题文章: